Can we have a different 'from' and 'reply to' email address?

Hi! For our community, we do want to set a different from (noreply@) emailaddress than the reply to emailaddress (info@) . Is it possible to configure different emailaddresses in the community for 'from' and 'reply to'? And does it matter if you have access to the mail server for the 'reply to' emailaddress that you set, or can I hypothetically add any emailaddress?

Thanks!